At present, there is no angiogenesis imaging agent focused on both vascular endothelial adhesiveness and cellular targets. SC-01 interacts with vascular endothelial and cellular targets. SC-01 also has multiple amino and carboxylic groups, which allows anticancer drug conjugate for targeted imaging and therapy. Our data indicate that 99mTc- SC-01 accumulates more actively in the nucleus as well as cytoplasm of breast tumor cells. SC-01 could follow-up treatment outcome. Due to favorable physical characteristics and its low cost, 99mTc has been preferred for labeling radiopharmaceuticals. Thus, labeling SC-01 with 99mTc is anticipated to be stable and with high radiochemical purity.
The primary objective is based on the evaluation of safety whereas secondary objectives are to determine the best dose, optimal time and biodistribution of SC-01 in patients with breast cancer on planar and single photon emission computed tomography/computed tomography (SPECT/CT) images acquired at multiple imaging time points after each administration of SC-01. The biodistribution of SC-01 will be studied for the aim of implementing the highest tolerated dose in future studies for diagnostic and therapeutic aims in breast cancer patients. Data generated is intended to help identify appropriate dose and timing of SC-01 administration and imaging for subsequent trials. The imaging data obtained from SC-01 provides predictive radiation dosimetry value for 188Re-SC-01 and/or SC-01-drug conjugates. Therefore, the data obtained from this study not only provide an impact on improving the diagnosis of breast cancer through the application of SC-01 but also provide a basis for internal radionuclide targeted therapy.
PUBLISHED ARTICLES IN REFERRED JOURNALS
- Wei I-Chien, Tsao Ning, Huang Y-H, Ho Y-S, Wu C-C, Yu D-F, Yang DJ. 99mTc-glycopeptide: synthesis, biodistribution and imaging in breast tumor-bearing rodents. Applied Radioan and Isotopes 2008; 66:320-331.
- Tsao Ning, Wang CH, Her LJ, Tzen KY, Chen JY, Yu DF, and Yang DJ. Development of 68Ga-Glycopeptide as an imaging probe for tumor angiogenesis. Journal of Biomedical and Biotechnology. 2011: 267206
- Wei I-C, Tsao Ning, Huang YH, Huang CC, Yang DJ. Ho Y-S, Chanda M, Wu CC, Kurihara H, Kohanim S, Oh C-S, Kim EE. Development of GP as a cell penetrating carrier for cancer therapy. 2007 Annual Meeting of the AAPS in San Diego, CA (Nov 11-15, 2007) Pharm Res 2007 (Abstract 1082).
- Tsao Ning, Wei I-C, Huang YH, Yang DJ. Ho Y-S, Wu CC, Oh C-S, Kurihara H, Kohanim S, Yu D-F, Kim EE. Safety, biodistribution, dosimetry and breast tumor imaging potential of Tc-99m-glycopeptide. 2007 Annual Meeting of the AAPS in San Diego, CA (Nov 11-15, 2007) Pharm Res 2007 (Abstract 1084).
- Huang YH, Wei I-C, Tsao Ning, Yang DJ. Ho Y-S, Oh C-S, Wu CC, Kurihara H, Kohanim S, Yu D-F, Kim EE. Targeting tumor angiogenesis using glutamate transporter-based glycopeptide 2007 Annual Meeting of the AAPS in San Diego, CA (Nov 11-15, 2007) Pharm Res 2007 (Abstract 1085).
- Tsao Ning, Wei I-C, Huang YH, Yang DJ, Ho Y-S, Wu CC, Oh C-S, Kurihara H, Kohanim S, Yu D-F, Kim EE. Glycopeptide: tissue distribution and efficacy assessment of antiangiogenic therapy. 2007 Annual Meeting of the AAPS in San Diego, CA (Nov 11-15, 2007) Pharm Res 2007 (Abstract 1083).
- Tsao Ning, Yang DJ, Wei I-C, Huang Y-H, Huang C-C, Chanda M, Kurihara H, Kohanim S, Oh C-S, Kim EE. Biodistribution and imaging of Ga-68 and Tc-99m-glycopeptide-methotrexate (GP-MTX) in rodents. 55th Annual Meeting of the Society of Nuclear Medicine. New Orleans, LA, June 14-18, 2008. J Nucl Med 2008; 49(Supp.1):331P. (abstract 1402).
- Tsao Ning, Oh C, Kohanim S, Yu D-F, Chanda M, Tzen K, Yang DJ. Synthesis of 68Ga-Glycopeptide as an imagng probe for tumor angiogenesis. 2010 Annual Meeting of the AAPS in New Orleans, LA, November 13-18, 2010. Pharm Res 2010 (Abstract SA 8205).
- Tsao Ning, Yu DF, Yang DJ. Glutamate transporter as a target for image-guided therapy in breast cancer. 59th Annual Meeting of the Society of Nuclear Medicine. Miami, Florida, June 9-13, 2012. J Nucl Med 2012 (Oral presentation, Abstract 06).
- Tsao Ning, Yu DF, Yang DJ. Glycopeptide as a Tool for Tumor Theranostic Applications. 2012 Annual Meeting of the AAPS in Chicago, IL, October 14-18, 2012. Pharm Res 2012 (Abstract AM-12-00872).